סמינר בכימיה פיזיקלית: Unique DNA memories

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Abstract:

DNA is the ultimate storage device. In the first part of this presentation, I will cover our studies on using DNA as a digital storage device. We devised a ‘DNA-of-things’ (DoT) storage architecture to produce materials with immutable memory. In a DoT framework, DNA molecules record the data, and these molecules are then encapsulated in nanometer silica beads, which are fused into various materials used to print or cast objects in any shape. DoT could be applied to store electronic health records in medical implants, to hide data in everyday objects and to manufacture objects containing their own blueprint. In the second part of this presentation, I will present DELiveri, a method that harnesses DNA-encoded libraries (DEL) to conduct high throughput screens of conjugates that promote the delivery of nucleic acid therapeutics. We utilized this platform for multiple partnerships with pharma companies, collecting massive datasets on the structure-activity relationship of conjugates the promote cellular delivery. 

מארגן הסמינר: פרופ' יובל אבנשטיין